how anesthesia works !!!

 

 MECHANISM OF ACTION OF THE GENERAL ANESTHESIA

General anesthesia has been around for more than 170 years but the exact mechanism of action of how it works is still unknown to us. What we have are theories.

But in recent years thanks to the technologies and extensive research we have been supplanted by the unitary method which targets the molecular level of the organ like the CNS at different levels.

What does the anesthetics do with the CNS?

 Mostly they affect the different cellular locations of the neuron most of which is the synapse. In the synapse, they alter the pre and postsynaptic locations. If they act at the presynaptic locations then they alter the release of the neurotransmitters and if they alter the postsynaptic neuron then they change the frequency of the impulse conduction.

At the organ level, it means that there will be an inhibition strengthen or weakened excitation of the central nervous system and thus the stimulus will not be interpreted.

Well, more the anesthetics work to diminish the excitation than the inhibition.

The Ion Channels that are inhibited by the anesthetics

Chloride channels (γ-aminobutyric acid-A [GABAA] and glycine receptors) and potassium channels (K2P, possibly KV, and KATP channels) remain the primary inhibitory ion channels considered legitimate candidates of anesthetic action.

These channels are inhibited by the anesthetics

The Ions Channels That Are Excited by the Anesthetics

 Excitatory ion channel targets include those activated by acetylcholine (nicotinic and muscarinic receptors), by glutamate (amino-3-hydroxy-5-methyl-4-isoxazole propionic acid [AMPA], kainate, and N-methyl-d-aspartate [NMDA] receptors), or by serotonin (5-HT2 and 5-HT3 receptors).

Conclusion

 This was just a simple way in which general anesthesia alters the way how our central nervous system works. There is a detailed function of each and every anesthetic agent we take whether it be intravenous or inhalational and thus I hope we will try to learn about it more in the future.

Hope you found today's information relevant and might find it useful any day.

Stay safe, informed, and healthy

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